physalin F ( —— )

产品货号. M22596 CAS No. 57423-71-9

Physalin F 是 CaV2.3（R 型）和 CaV2.2（N 型）电压门控钙通道的天然阻断剂。它是一种具有有效抗炎和免疫调节活性的类固醇。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥4828	有现货
10MG	￥6990	有现货
25MG	￥10368	有现货
50MG	￥13932	有现货
100MG	￥18873	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

physalin F
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Physalin F 是 CaV2.3（R 型）和 CaV2.2（N 型）电压门控钙通道的天然阻断剂。它是一种具有有效抗炎和免疫调节活性的类固醇。
产品描述

Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infectionPhysalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities.?A concentration-dependent inhibition of spontaneous proliferation of PBMC from HAM/TSP subjects was observed in the presence of physalin F, as evaluated by (3)H-thymidine uptake.?The IC50 for physalin F was 0.97 0.11 μM.?Flow cytometry analysis using Cytometric Bead Array (CBA) showed that physalin F (10 μM) significantly reduced the levels of IL-2, IL-6, IL-10, TNF-α and IFN-γ, but not IL-17A, in supernatants of PBMC cultures.?Next, apoptosis induction was addressed by using flow cytometry to evaluate annexin V expression.?Treatment with physalin F (10 μM) increased the apoptotic population of PBMC in HAM/TSP subjects.?Transmission electron microscopy analysis of PBMC showed that physalin F induced ultrastructural changes, such as pyknotic nuclei, damaged mitochondria, enhanced autophagic vacuole formation, and the presence of myelin-like figures.?In conclusion, physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by HTLV-1 infection.
体外实验

Physalin F is a seco-steroid from Physalis angulate L..
体内实验

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同义词

——
通路

Apoptosis
靶点

Apoptosis
受体

Apoptosis
研究领域

——
适应症

——

化学信息

CAS Number

57423-71-9
分子量

526.5
分子式

C28H30O10?
纯度

>98% (HPLC)
溶解度

——
SMILES

[H][C@@]12C(=O)[C@]34O[C@]11[C@@](C)(OC(=O)[C@@]1(O)CC[C@@]1([H])[C@@]3([H])C[C@H]3O[C@]33CC=CC(=O)[C@]13C)[C@H]1C[C@]2(C)[C@@]([H])(CO4)C(=O)O1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Pinto L A , Meira, Cássio S, Villarreal C F , et al. Physalin F, a seco-steroid from Physalis angulata L. has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy[J]. Biomedicine & Pharmacotherapy, 2016, 79:129-134.

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